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Bradford Ophthalmology Research Network (BORN)

Overview of the Research

Who We Are

We are one of the most experienced clinical research teams engaged in eye and vision research in the UK. The team has 2 research nurses, 1 research fellow, 1 clinical trial assistant, 3 research optometrists, and 3 accredited ophthalmic photographers.

BORN have facilitated over 50 clinical trials since 2008 and recruited over 500 participants to these trials.

Through our research and partnerships, the team has invested in new state of the art equipment for the ophthalmology and macular clinics such as Multimodal retinal imaging, Fluorescein and Indocyanine green angiography, Fundus Auto Fluorescence, Optical Coherence Tomography (OCT), OCT angiography, OPTOS wide field camera and Micro-Pulse Laser.

Mission Statement

  • Increase and improve research activity within Ophthalmology and embed it into everyday practice.
  • Promote science, education and innovation for clinical care in ophthalmology.
  • Make research common practice, that is valued and available to all.
  • Value patients and their contribution to clinical research and provide safe, quality care
  • Promote best practice when caring for patients with ophthalmological conditions

 

Our main priorities are acting in the best interests of our patients, providing high quality care and safety within ophthalmic research. Our success as a research team is due to our patients who have kindly volunteered to help with our research projects over the years.

Contact Us

Interested in getting involved with ophthalmic research?

Contact the team :
E: Eye.Research@bthft.nhs.uk 

Follow us on Twitter @BTHFTeye_res

The Research Team

Prof Faruque Ghanchi

Consultant Ophthalmologist

Miss Helen Devonport

Miss Helen Devonport

Consultant Ophthalmologist

Mr Murtuza Mookhtiar

Consultant Ophthalmologist

Dr Sridevi Rajasekaran

Dr Sridevi Rajasekaran

Research Fellow

Dr Charlotte Hazel

Research Optometrist

Mr Faizaan Azmi

Mr Faizaan Azmi

Research optometrist

Dr Corinne Fulcher

Research Optometrist

Nicci Hawes

Lead Research Nurse

Sarah Moss

Research Nurse

Lorraine Terry

Lorraine Terry

Clinical Trials Assistant

Our Research 

LATEST RESEARCH

Current Research

RHONE-X – Faricimab vs Aflibercept in patients with Diabetic Macular Oedema – open label extension

AVONELLE-X – Faricimab vs Aflibercept in patients with Wet Age Related Macular Degeneration – open label extension

COMINO – Faricimab Vs Aflibercept in central retinal vein occlusion or hemi-retinal vein occlusion

EYE-NEON – Artificial Intelligence monitoring of potential nAMD in fellow eye

ADVISE – Uveitis

TELESCOPE – Geographic atrophy.

ASTUTE – Uveitis

HORNBILL – first in human trial for diabetic macular ischaemia

ALLUVIUM – Phase 2 study of IL-6 inhibitor for diabetic macular oedema

BARDENAS – Phase 2 of IL-6 inhibitor plus Ranibizumab for diabetic macular oedema

EVIAN – treatment for post operative exogenous endophthalmitis

Achievements

Over the past 12 years in research we have had a number of accolades:

  • Bayer Ophthalmology Judge’s Special Award December 2016 for innovation and determination in developing a strong ophthalmology research team
  • 1st Global Patient for Constance study 2012
  • 1st rest of world patient for pSivida, 2014
  • 1st Uk patient for proxima B 2015
  • Fastest recruiter in UK (within a week) for the Polaris Study, 2013
  • Top recruiting site (UK) October 2015 – LEAVO study
  • 1st UK patient RHINE (2018)
  • 1st Rest of World patient TENAYA (2019)
  • Fastest and Highest recruitment in the UK TENAYA (2019)
  • 1st UK Patient COMINO (2021)

Other achievements, e.g., radio/TV appearances/newspaper articles include any publications

http://www.thetelegraphandargus.co.uk/news/11831689.State_of_the_art_eye_scanner_cements_hospital_s_place_at_forefront_of_eye_research/

http://www.thetelegraphandargus.co.uk/news/health/11099506.Pioneering_implant_trial_could_transform_lives/

http://www.thetelegraphandargus.co.uk/news/9700177.Drugs_trial_could_save_NHS___84m/

http://www.thetelegraphandargus.co.uk/news/13325587.Volunteers_sought_for_ground_breaking_research_in_Bradford_into_condition_causing_blindness/

http://www.thetelegraphandargus.co.uk/news/13592924.Dedicated_eye_treatment_volunteer_celebrates_90th_birthday_in_research_unit/

Ghanchi FD, Hazel CA. South Asian Diabetic Macular Oedema treated with Ranibizumab (ADMOR) – http://www.nature.com/eye/journal/vaop/ncurrent/full/eye2015209a.html

Fulcher C, McGraw PV, Roach NW, Whitaker D, Heron J. Object size determines the spatial spread of visual time. In: Proc. R. Soc. B 2016 Jul 27 (Vol. 283, No. 1835, p. 20161024). The Royal Society.

Current Research

RHINE – Faricimab vs Aflibercept in patients with Diabetic Macular Oedema – open label extension commenced RHONE-X

TENAYA – Faricimab vs Aflibercept in patients with Wet Age Related Macular Degeneration – open label extension commenced AVONELLE-X

TALON – Brolicizumab vs Aflibercept modified treatment pathway for Wet Age Related Macular Degeneration

COMINO – Faricimab Vs Aflibercept in central retinal vein occlusion or hemi-retinal vein occlusion

EYE-NEON – Artificial Intelligence monitoring of potential nAMD in fellow eye

ADVISE – Uveitis

TELESCOPE – Geographic atrophy.

ASTUTE – Uveitis

 

 

Industry Partners

Alcon

Allergan

Bayer

Novartis

Oraya

pSivida

Santen

Roche

Bioeq GmbH

SYNEOS Health

O4 Research

Covance

Iqvia

Achievements

Over the past 12 years in research we have had a number of accolades:

  • Bayer Ophthalmology Judge’s Special Award December 2016 for innovation and determination in developing a strong ophthalmology research team
  • 1st Global Patient for Constance study 2012
  • 1st rest of world patient for pSivida, 2014
  • 1st Uk patient for proxima B 2015
  • Fastest recruiter in UK (within a week) for the Polaris Study, 2013
  • Top recruiting site (UK) October 2015 – LEAVO study
  • 1st UK patient RHINE (2018)
  • 1st Rest of World patient TENAYA (2019)
  • Fastest and Highest recruitment in the UK TENAYA (2019)
  • 1st UK Patient COMINO (2021)

Other achievements, e.g., radio/TV appearances/newspaper articles include any publications

http://www.thetelegraphandargus.co.uk/news/11831689.State_of_the_art_eye_scanner_cements_hospital_s_place_at_forefront_of_eye_research/

http://www.thetelegraphandargus.co.uk/news/health/11099506.Pioneering_implant_trial_could_transform_lives/

http://www.thetelegraphandargus.co.uk/news/9700177.Drugs_trial_could_save_NHS___84m/

http://www.thetelegraphandargus.co.uk/news/13325587.Volunteers_sought_for_ground_breaking_research_in_Bradford_into_condition_causing_blindness/

http://www.thetelegraphandargus.co.uk/news/13592924.Dedicated_eye_treatment_volunteer_celebrates_90th_birthday_in_research_unit/

Ghanchi FD, Hazel CA. South Asian Diabetic Macular Oedema treated with Ranibizumab (ADMOR) – http://www.nature.com/eye/journal/vaop/ncurrent/full/eye2015209a.html

Fulcher C, McGraw PV, Roach NW, Whitaker D, Heron J. Object size determines the spatial spread of visual time. In: Proc. R. Soc. B 2016 Jul 27 (Vol. 283, No. 1835, p. 20161024). The Royal Society.

HISTORICAL RESEARCH

Previous Research:

VPDT, IVAN, COMRADE B, COMRADE C, SAKURA, INTREPID, POLARIS, IVAN B, SAFARI, LUMINOUS< ASH< CONSTANCE, INJECT, DREAMS, pSIVIDA, LEAVO, SPECTRI, PROXIMA B, OMASPECT, EDNA, COLUMBUS, CENTERA, VICI, FASBAT, OCTANE, EMERALD, DIAMONDS, RAPTOR, PANDA-2, DRAKO, PRECISE, RHINE, TENAYA, TALON, BESRA