Bradford Children’s Research Team

Overview 

Our research interests include: Rheumatology, ENT, Neonates, Diabetes, General Medicine, Asthma and Childhood Diseases

Bradford Children’s Research gives babies, children, young people and their families the opportunity to be involved in research that will improve treatments and care for future generations. Together we hope to make researching the effectiveness of new and existing treatments part of routine care.

The Research Team

Dr Sam Oddie

Consultant Neonatologist

Rachel Swingler

Research Sister

Charlene Bass-Woodcock

Research Sister

Rachel Wane

Lead Research Sister

Liz Ingram

Clinical Trials Officer

LATEST RESEARCH

SuperTRIAL – Phase 2b trial of BPZE1 Nasal Spray Vaccine in Healthy Children www.supertrial.co.uk

Interpreted conversations between doctors and parents in prenatal and neonatal care: a conversation analytic study

FEED-1- A randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age) https://feed1.ac.uk/home.aspx

AZTEC (Azithromycin Therapy for Chronic Lung Disease of Prematurity) Follow up studies: AZTEC@1 and AZTEC@2

BCRD- Biologics for Children with Rheumatic Diseases

BioJUME- Biology of Juvenile Myoclonic Epilepsy. More details available on http://childhoodepilepsy.org/research-studies/biojume/

BSPAR- BSPAR Etanercept Cohort Study

CF Start- The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF. More details on  www.cfstart.org.uk

Extended Biologics- The Long-term Safety and Efficacy of Biologic Therapies in Children with Rheumatic Diseases.

ITP registry- UK childhood ITP registry

JDCBS- Juvenile Dermatomycosis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies

JSLE- UK Juvenile Systematic Lupus Erythematosus Cohort Study and Repository

SCIENCE – Surgery or Cast for Injuries of the EpicoNdyle in Children’s Elbows.

HISTORICAL RESEARCH

What’s The STORY – Sero-epidemiological survey of England in 2019/2020. www.whatsthestory.org.uk 

AZTEC – The Azithromycin therapy for Chronic Lung Disease of Prematurity. www.cardiff.ac.uk/aztec

RECOVERY – Randomised Evaluation of COVID-19 Therapy  http://www.recoverytrial.net 

Raaceno- Reducing asthmA attAcks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy- a randomised trial. More info on https://www.raaceno.co.uk/

NeoCLEAR – Optimising Lumbar Punctures in Newborns. For more information, please visit https://www.npeu.ox.ac.uk/neoclear

BabyOSCAR – Outcome after Selective Early Treatment for Closure of Patent Ductus ARteriosus in Preterm Babies https://www.npeu.ox.ac.uk/baby-oscar

Archie- The early use of Antibiotics in at Risk Children with Influenza

Boss- British Orthopaedic Surgery Surveillance study. More details on http://www.boss.surgery/

Elfin- A multi-centre randomised placebo-controlled trial of prophylactic Enteral Lactoferrin supplementation to prevent late-onset invasive infection in very preterm infants. More details on : https://www.npeu.ox.ac.uk/ELFIN

GSK 204959- Clinical trial in patients with eosinophilic asthma.

Jump- Type 2 Diabetes in Childhood: Building a platform for interventions to prevent the progression to cardiovascular disease. More information on : http://www.jump.bham.ac.uk/

Magpie- Mechanisms Affecting the Gut of Preterm infants in Enteral feeding studies. More info on : www.npeu.ox.ac.uk/magpie

MERIDIAN – Magnetic resonance imaging to enhance the diagnosis of foetal developmental brain abnormalities in utero (MERIDIAN). 2-3 year follow-up study

Mini Dex- The efficacy and safety of very low dose dexamethasone used to facilitate the extubation of ventilator dependent preterm babies who are at high risk of bronchopulmonary dysplasia. More info on www.npeu.ox.ac.uk/minidex

Optisurf – The effect of Surfactant dose on outcomes in preterm infants with Respiratory Distress Syndrome

RaDar – The National Registry of Rare Kidney Diseases

Kawasaki – Genetic determinants of Kawasaki disease for susceptibility and outcome

OSTRICH- Oral STeroids for The Resolution of Otitis media with effusion in Children study.

PIC Study- Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for the Management of Fever and Non-Blanching Rashes In Children Including the Role of Point of Care Testing for Procalcitonin & Neisseria Meningitidis DNA.

Planet 2- A randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates. More info on http://www.planet-2.com/

Prednos – Long-term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome. More info on : http://www.bctu.bham.ac.uk/PREDNOS

PREVAILPREVenting infection using Antimicrobial Impregnated Long lines. Further information can be found on http://www.prevailtrial.org.uk/

REDEXAM- reducing painful eye examinations in preterm infants

SIFTA multi-centre randomised controlled trial of two speeds of daily increment of milk feeding in very preterm or very low birth weight infants. More information can be found on: www.npeu.ox.ac.uk/sift

TEVAA Single Visit, Open-Label Study of the Accuracy of measurement of the Maximum Inhalation Flow (MIF) of Patients With Asthma or COPD Using an Electronic Multi-dose Dry Powder Inhaler (eMDPI)

UK-Chimes – UK Childhood Meningitis and Encephalitis cohort Study

WAIT- Wheeze and intermittent treatment – a non- steroid oral medication for wheezing.

IMPACT OF RESEARCH

Click the links below to access the published papers from Historical Research:

CORD – Randomised trial of cord clamping and initial stabilisation at very preterm birth. https://fn.bmj.com/content/103/1/F6

ELFIN – A multi-centre randomised placebo-controlled trial of prophylactic Enteral Lactoferrin supplementation to prevent late-onset invasive infection in very preterm infants. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32221-9/fulltext

MERIDIAN – Magnetic resonance imaging to enhance the diagnosis of foetal developmental brain abnormalities in utero.    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31723-8/fulltext

OSTRICH- Oral STeroids for The Resolution of Otitis media with effusion in Children study. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31490-9/fulltext

Planet 2 – A randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates. https://www.nejm.org/doi/full/10.1056/NEJMoa1807320

PREVAIL – PREVenting infection using Antimicrobial Impregnated Long lines. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(19)30114-2/fulltext

REDEXAM – Reducing painful eye examinations in preterm infants. https://www.nature.com/articles/pr2017179.pdf?origin=ppub