Andrew Clegg Photo

Dr Andrew Clegg

Clinical Senior Lecturer in Geriatric Medicine

andrew.clegg@bthft.nhs.uk

ORCID: 0000-0001-5972-1097

Andy is an academic geriatrician with research interests in frailty, delirium and dementia. He is currently deputy lead for the Yorkshire & Humber NIHR CLAHRC Older People’s Theme, entitled ‘Primary care-based management of frailty in older people’.

Andy is CI for an NIHR Programme Grant to optimise and evaluate personalised care planning for older people with frailty and CI for the NIHR HTA-funded Home-based Extended Rehabilitation for Older People (HERO) trial. Andy is also CI for the Community Ageing Research 75+ (CARE 75+) multi-site cohort study to investigate frailty, disability and quality of life trajectories in older age, and evaluate interventions to improve outcomes using a novel ‘trial within cohort’ (TWiCs) design.

 

Andy led the development, validation and implementation of the award winning and NICE-recommended electronic frailty index (eFI) using data from around 1M UK patients contained in the ResearchOne and THIN primary care research databases.

Key publications include a 2013 Lancet seminar review on frailty in elderly people and a Cochrane review on interventions for preventing delirium in older people in long-term care. Andy was a member of the 2016 NICE multi morbidity guideline development group, the 2010 NICE delirium guideline development group and the NHS Evidence advisory panel. Andy referees applications for the NIHR and MRC, and is a reviewer for the Lancet, BMJ and Age & Ageing journals.

Recent Funding Awarded

Clegg A, Young J, Bower P, Cundill B, Farrin A, Foster M, Foy R, Hartley S, Hawkins R, Hulme C, Humphrey S, Pendleton N, Teale E, West R, Holmes J. Personalised care planning to improve quality of life for older people with Frailty. NIHR, Programme Grants for Applied Research £2,754,006; 01/09/2017-31/12/ 2022 (64 months).

Clegg A, Young J, Forster A, Farrin A, Hartley S, Hulme C, Clarke D, Wright P, Cundill B. Randomised controlled trial evaluation to determine the clinical and cost effectiveness of a Home-based exercise intervention as Extended Rehabilitation in Older people with frailty following acute illness or injury, including internal pilot and embedded process evaluation (HERO). NIHR HTA £2,038,930.19; 01/03/2017- 31/05/2021 (51 months).

Young J, Clegg A, Nolan M, Mountain G, Teale E, Spilsbury K, Hanratty B, Noble B, Parry J Bates C, Hawkins R, Astell A, Young T. Primary Care-Based Management of Frailty in Older People. NIHR CLAHRC, £999,868; 01/01/2014-31/12/2018.

Clegg A, Young J. The Home-Based Older People’s Exercise (HOPE) Programme. An exercise programme to improve the functional status of community-dwelling frail older people. Royal College of Physicians & Dunhill Medical Trust Research Fellowship. £109,536, 01/10/09 – 31/09/2011.

Recent Publications

Witham MD, Roberts HC, Gladman J, Stott DJ, Aihie Sayer A, Aspray TJ, Brock P, Clegg A, Cox N, Ewan V, Frith J, Burton JK, Jackson T, Lewis EG, Lim SE, Makin S, Lochlainn MN, Richardson S, Shenkin SD, Steves CJ, Todd O, Tullo E, Walker R, Yarnall A. Extended Working Group* from the NIHR Newcastle Biomedical Research Centre Meeting. Growing research in geriatric medicine. Age Ageing. 2019 [online] doi: 10.1093/ageing/afy220

Brown L, Young J, Teale E, Santorelli G, Clegg A. A Cross-Sectional Study of the Impact of Pain in Older People with Frailty: Findings from the Community Ageing Research 75+ (CARE75+) Study. Advances in Geriatric Medicine and Research 2019;1:e190002. https://doi.org/10.20900/agmr20190002

Heaven A, Brown L, Young J, Teale E, Hawkins R, Spilsbury K, Mountain G, Young T, Goodwin V, Hanratty B, Chew-Graham C, Brundle C, Mahmood F, Jacob I, Daffu-O’Reilly A, Clegg A. Community ageing research 75+ study (CARE75+): an experimental ageing and frailty research cohort. BMJ Open 2019;9(3):e026744. doi: 10.1136/bmjopen-2018-026744

Crocker TF, Brown L, Clegg A, Farley K, Franklin M, Simpkins S. Young J. Quality of life is substantially worse for community-dwelling older people living with frailty: systematic review and meta-analysis. Quality of Life Research 2019:1-16 https://doi.org/10.1007/s11136-019-02149-1

Brundle C, Heaven A, Brown L, Teale E, Young J, West R, Clegg A. Convergent validity of the electronic frailty index. Age Ageing 2019;48(1):152-156.

Wilkinson C, Todd O, Clegg A, Gale CP, Hall M. Management of atrial fibrillation for older people with frailty: a systematic review and meta-analysis. Age Ageing 2018 doi: 10.1093/ageing/afy180. [Epub ahead of print]

Reeves D, Pye S, Ashcroft D, Clegg A, Kontopantelis E, Blakeman T, VanMarwijk H. The challenge of ageing populations and frail people: can primary care adapt? BMJ 28;362:k3349. doi: 10.1136/bmj.k3349.

Clegg A, Hassan-Smith Z. Frailty and the endocrine system. Lancet Diabetes and Endocrinology 2018;6(9):743-752. doi: 10.1016/S2213-8587(18)30110-4

Stow D. Hanratty B, Robinson L, Barclay SIG, Iliffe S, De-Biase S, Clegg A, Matthews F. Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: case control study. Age Ageing 2018. doi: 10.1093/ageing/afy022

Pugh R, Ellison A, Pye K, Subbe CP, Thorpe CM, Lone NI, Clegg A. Feasibility and reliability of frailty assessment in the critically ill: a systematic review. Critical Care 2018; 22:49. doi: 10.1186/s13054-018-1953-9.

Bebb O, Smith FGD, Clegg A, Hall M, Gale CP. Frailty and acute coronary syndrome: A structured literature review. European Heart Journal: Acute Cardiovascular Care 2017 (online). doi.org/10.1177/2048872617700873

Teale EA, Siddiqi N, Clegg A, Todd OM, Young J. Non-pharmacological interventions for managing delirium in hospitalised patients. 2016 Mar 11;3:CD005563. doi: 10.1002/14651858.CD005563.pub3.

Clegg A, Bates C, Young J, Ryan R, Nichols L, Teale EA, Mohammed MA, Parry J, Marshall T. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age and ageing. 2017;5(3):353-60. doi: 10.1093/ageing/afw039.

Yarnall AJ, Sayer AA, Clegg A, Rockwood K, Parker S, Hindle JV. New horizons in multimorbidity in older adults. Age and Ageing. 2017;46(6):882-888.

Todd O, Clegg A. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. The New England journal of medicine. 2016;374:2290-2295.doi: 10.1056/NEJMc1602668

Heaven A. Brown L, Foster M; Clegg A. Keeping it credible in cohort multiple Randomised Controlled Trials: the Community Ageing Research 75+ (CARE 75+) study model of patient and public involvement and engagement Research Involvement and Engagement 2016doi: 10.1186/s40900-016-0044-9.

Clegg A, Bates C, Young J, Ryan R, Nichols L, Teale E, Mohammed MA, Parry J, Marshall T Development and validation of an electronic frailty index using routine primary care electronic health record data Age Ageing 2016;45(3):353-60.

Siddiqi N, Harrison JK, Clegg A, Teale EA, Young J, Taylor J, Simpkins SA. Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database of Systematic Reviews 2016; DOI 10.1002/14651858.CD005563.pub3. Issue 3.

Clegg A, Young J. Frailty and organization of health and social care. In:Frailty in Aging: Biological, Clinical and Social Implications. Editors: O Theou, K Rockwood. Karger 2015;48:161-173.

Brown L, Young Y, Clegg A, Heaven A. Pain in older people with frailty. Reviews of Clinical Gerontology 2015;25(03): 159-171.

Harrison J, Clegg A, Conroy S, Young J. Managing frailty as a long-term condition. Age Ageing 2015;44:732–735.

Clegg A, Young J. Frailty and Organization of Health and Social Care. Interdisciplinary topics in gerontology and geriatrics 2015;41:161-173.

Siddiqi N, Clegg A, Simpkins SA, Young J, Holt R, Harrison JK, Taylor J. Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database of Systematic Reviews 2015;1. Art. No.: CD005563. DOI: 10.1002/14651858. CD005563.pub2.

Clegg A,Rogers L, Young J.Diagnostic test accuracy of simple instruments for identifying frailty in community dwelling older people. Age Ageing 2015;44(1):148-152.

Clegg A,Relton C, Young J,Witham M. Improving recruitment of older people to clinical trials: use of the cohort multiple randomised controlled trial design. Age Ageing 2015;44(4):547-550.

Handforth C, Clegg A,Young C, Simpkins S, Seymour MT, Selby P, Young J.The prevalence and outcomes of frailty in older cancer patients: a systematic review. Annals of Oncology 2015; 26(6):1091-1101.

Heaven A,Cheater F, Clegg A, Collinson M, Farrin A, Forster A, Godfrey M,et al. Pilot trial of Stop Delirium! (PiTStop) – A complex intervention to prevent delirium in care homes for older people: study protocol for a cluster randomised controlled trial. Trials 2014;15:47.

Turner G, Clegg A.Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. Age Ageing 2014;43(6):744-747.

Clegg A, Bates C, Young J, Teale E, Parry J. Development and validation of an electronic frailty index using existing primary care health record data. Age Ageing 2014;43(2):ii19. [Abstract].

Clegg A, Barber S, Young J, Iliffe S, Forster A. (HOPE) trial: a pilot randomised controlled trial of a home-based exercise intervention for older people with frailty. Age Ageing 2014;43(5):687-695.

Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. The Lancet 2013; (9868): 752-62.

Clegg A, Young J, Siddiqi N. Delirium in cardiac patients: a clinical review. British Journal of Cardiac Nursing 2012; 7(3): 111-5.

Clegg A, Siddiqi N, Holt R, Young J. Interventions for preventing delirium in older people in institutional long-term care (protocol). Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD009537. DOI: 10.1002/14651858.CD009357.

Clegg A, Barber S, Young J, Forster A, Iliffe S. Do home-based exercise interventions improve outcomes for frail older people? Findings from a systematic review. Reviews in Clinical Gerontology 2012 22;68-78.

Barber S, Clegg A, Young J. Is there a role for physical activity in preventing cognitive decline in people with mild cognitive impairment? Age Ageing 2012;41:5-8.

Clegg A, Young J. In-hospital delirium risk assessment, diagnosis and management: medications to avoid. Italian Journal of Medicine 2011;5:98-102.

Clegg A, Barber S, Young J, Forster A, Iliffe S. The Home-Based Older People’s Exercise (HOPE) trial: study protocol for a randomised controlled trial. BMC Trials 2011;12:143.

Clegg A, Young J. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing Jan 2011; 40(1):23-29.

Clegg A, Young J. The Frailty Syndrome. Clinical Medicine 2011;11(1):72-75.

Clegg A, Westby M, Young J. Under-reporting of delirium in the NHS. Age Ageing Mar 2011; 40(2):283-286.

Clegg A, Smith S. Gerotechnology series: bedding aids. European Geriatric Medicine. 2010; 1(6): 385-390.

Clegg A, Daverede L, Wong W, Loney E, Young J. Recurrent syncope and chronic ear pain. BMJ Case Reports 2010; 1-3.

Siddiqi N; Clegg A; Young J. Delirium in care homes. Reviews in Clinical Gerontology 2009; 19:309-316.

Clegg A, Young J. Frailty and organization of health and social care. In:Frailty in Aging: Biological, Clinical and Social Implications. Editors: O Theou, K Rockwood. Karger 2015;48:161-173.