Infectious Diseases & Sexual Health Research Team

Overview of the Research

Infectious diseases research at Bradford Teaching Hospitals NHS Foundation Trust was established in June 2012, and covers a wide range of systems and diseases with a large untapped research potential. Since its inception, the infection research team at BTHFT have worked tirelessly to increase the available portfolio of studies and now have a large ongoing portfolio of research trials/studies covering a range of infection interests including Hospital Acquired Infections, CNS infections, HIV, flu and Sexual Health. We are constantly updating our portfolio to cover more infections and diseases, to ensure that high quality research can be offered to all who wish to be involved, delivered by compassionate and knowledgeable staff. Studies suggest that patients who receive care in research-active institutions have better health outcomes than patients who are treated in a non-research environment.

We currently participate in both non-commercially and commercially funded research. Providing care for patients involved in interventional and observational research.

The Research Team

Dr Paul McWhinney

Consultant in Infectious Diseases

Dr Nicola Fearnley

Consultant in Genitourinary Medicine

Dr Sophie Brady

Consultant in Genitourinary Medicine

Dr Riccardo Giuntini

Consultant in Infectious Diseases

Jackie Todd

Clinical Research Nurse

Sue Kimachia

Clinical Research Nurse

Judith Platt

Research Administrator

Lisa Burgess

Clinical Research Health Care Assistant.

Alison Haigh

Lead Pharmacist Antimicrobial Therapy

Our Research 

LATEST RESEARCH

Flu003 – Inpatients with Flu are enrolled to allow us to learn more about Influenza

Meningitis UK – Patient who are admitted with symptoms consistent with meningitis are enrolled to help us understand more about the condition and develop less invasive tests to help diagnose Meningitis.

Dex ENCEPH – Patients with a certain form of Encephalitis are enrolled.

POSY TIECO – This is a multicentre, post authorisation observational study to estimate the nephrotoxicity potential (toxic effect on the kidneys) of the higher loading dose of Teicoplanin

MERMAID – ARI- Patients with symptoms of a chest infection are invited to participate in this research. It is hoped that this research will provide information to better prepare for outbreaks of these infection and understand the different treatments for this infection.

ESBL. Patients with this infection are invited to participate in this pilot study.

SUPA – The purpose of this interventional trial is to evaluate the impact of a CBT-based intervention supporting uptake and adherence to antiretroviral therapy for participants with HIV.

We also deliver research which looks at the benefits of switching certain HIV drug regimens for MSD.

 

Future Projects

The team plans to re-establish research in sexual health. We are also collaborating with ICU on the ADAPT SEPSIS trial. Which aims to deliver a UK-wide multi-centre randomised controlled trial to determine whether treatment protocols based on monitoring daily CRP (C-reactive protein) or PCT (procalcitonin) safely allow a reduction in duration of antibiotic therapy in hospitalised adult patients with suspected sepsis. We intend to expand our portfolio to include trials exploring antimicrobial stewardship and interventions to support this.

We aim to expand our current HIV research portfolio and deliver research concerned with people who have TB and have been asked to collaborate as part of the SGUL INTERTB Consortium based at St Georges University Hospital London. This collaboratuion is working to develop UK research focussing on the treatment of TB

HISTORICAL RESEARCH

The Infection Research Team at BTHFT have completed a number of research trials and studies always meeting and exceeding expectations. These have involved patients with a range of conditions such as Clostridium difficile and, more recently, HIV and sexual health.

In 2012 to 2014 the team successfully enrolled patients at Bradford Teaching Hospitals NHS Foundation Trust into an international and commercial research trail which aimed to treat and reduce reoccurrence of clostridium difficile infection. 5 patients from this trust were provided with the opportunity to receive a new pharmaceutical treatment for Clostridium Difficile.

Clostridium difficile is the major cause of antibiotic-associated diarrhoea in the elderly over the last two decades C. difficile has emerged as a major healthcare associated infection.

The team enrolled over 150 participants into a research study which aimed to test the hypothesis that patients with asymptomatic C. difficile infection contribute to transmission of C. difficile in the hospital setting. This study has been published:

Behar, L., Chadwick, D., Dunne, A., Jones, C.I., Proctor, C., Rajkumar, C., Sharratt, P., Stanley, P., Whiley, A., Wilks, M. and Llewelyn, M.J., 2017. Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. Journal of Infection, 75(1), pp.20-25.

We have delivered a number of observational research studies which aim to improve the care and treatment and understand HIV .

These include: –

Partners of people on ART: a New Evaluation of the Risks PARTNER study.

The People Living with HIV Stigma Index 2015.

Seroconverter- UK Register of HIV Seroconverter

Positive Voices; The national survey of people living with HIV.

In 2014 research was successfully established within the sexual health service at Bradford Teaching Hospitals NHS Foundation Trust. This was a new research delivery area for the team. The team successfully recruited 175 clients attending for sexual health services into a research study to evaluate the performance of a new prototype rapid nucleic acid detection platform (Point of Care test) for Ct and Ng in uro-genital specimens. The accuracy of detection of Chlamydia and gonorrhoea. The following year a qualitative study was performed to obtain actual patient views.

The ID research team have always had an interest in research involving patients with brain infections such a s Encephalitis and Meningitis. The team enjoy a good working relationship with the Liverpool School of Tropical Medicine who sponsor these studies.

In 2015   The ID research team were involved with a trial of antibiotics to which aimed to determine whether the addition of 14 days rifampicin to initial standard antibiotic therapy reduced mortality ,bacteriological failure/death in patients with S. aureus bacteraemia. Staphylococcus aureus is a bug which can cause serious infections, including infections of the blood.

In addition to this our Lead Research Nurse has also carried out her own Qualitative research project which focuses on the provision of compassionate care for patients with infections and are nursed in isolation. This study is now complete and awaiting publishing.

We have a good working relationship with all of our sponsors and a reputation for providing high quality data and service provision.

IMPACT OF RESEARCH

The research delivered by the infection team has led to several published papers which demonstrate both impact and quality.

MSK have recently published this article in the public domain relating to the DRIVE group of trials   advising that the :FDA Accepts New Drug Applications for Merck’s Doravirine, the Company’s Investigational Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), for Treatment of HIV-1

http://www.mrknewsroom.com/news-release/corporate-news/fda-accepts-new-drug-applications-mercks-doravirine-companys-investigati

The research that we have delivered which aimed to test the hypothesis that patients with asymptomatic C. difficile infection contribute to transmission of C. difficile in the hospital setting. This study has been published:

Behar, L., Chadwick, D., Dunne, A., Jones, C.I., Procter, C., Rajkumar, C., Sharratt, P., Stanley, P., Whiley, A., Wilks, M. and Llewelyn, M.J., 2017. Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. Journal of Infection, 75(1), pp.20-25.

https://www.sciencedirect.com/science/article/pii/S0163445317301135